Academic journal article Environmental Health Perspectives

Extramurally Speaking ... (Merit Awards)

Academic journal article Environmental Health Perspectives

Extramurally Speaking ... (Merit Awards)

Article excerpt

The NIEHS is pleased to announce that Christopher A. Bradfield, a professor of oncology at the University of Wisconsin at Madison, and Michael B. Kastan, chairman of the Department of Hematology/Oncology at St. Jude Children's Research Hospital, have each received an award under the Method to Extend Research in Time (MERIT) Award Program. MERIT awards are offered to investigators who have demonstrated superior skill and outstanding productivity during the course of their previous research endeavors. MERIT awards relieve investigators from writing frequent renewal applications by providing the opportunity to gain up to 10 years of support in two segments.

Bradfield is interested in understanding the significance and role of the family of transcriptional regulators known as PAS proteins, which control a number of processes including xenobiotic metabolism, circadian rhythms, angiogenesis, and neurogenesis. For the past 10 years he has concentrated on the upstream events in the Ah receptor (AHR) signal transduction pathway and showing the importance of the PAS domain in binding and dimerization with its partner protein ARNT (AHR nuclear translocator). He has developed genetic systems in yeast and mice that allow first the identification of genes required in signaling pathways and then an understanding of the physiological function of the proteins. He is a recognized leader in the field of the mechanism of dioxin action, and his research is widely held to engage in state-of-the-art approaches with innovative applications. …

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