Academic journal article Environmental Health Perspectives

Fellowships, Grants, & Awards. (Announcements)

Academic journal article Environmental Health Perspectives

Fellowships, Grants, & Awards. (Announcements)

Article excerpt

Brain Disorders in the Developing World: Research across the Lifespan

This RFA solicits applications to plan and develop collaborative research and capacity-building projects on brain disorders throughout life relevant to low- and middle-income nations. Applicants will develop innovative collaborative research programs that will contribute to building sustainable research capacity in neurological/neurodevelopmental (including sensory, motor, cognitive, and behavioral) impairment.

This first phase of the "Brain Disorders in the Developing World: Research across the Lifespan" initiative will consist of two-year planning/development grants using the R21 grant mechanism. The R21 grant will provide support to initiate preliminary studies and to organize, plan, prepare, and assemble an application for a more comprehensive R01 grant involving collaboration between high-income and low- to middle-income country investigators and incorporating both research and capacity building. An RFA for the second competitive phase of this initiative is currently planned to be issued in fiscal year 2005. The main goals for this application are to assess needs, develop collaborations and needed resources, show feasibility, and generate preliminary data for the collaborative research to be proposed in a follow-up R01 submission.

The applicants should propose specific milestones and a timeline to meet these goals. Efforts must include pilot research projects to demonstrate feasibility of the research approaches and develop further research directions. Training, informal meetings, workshops, and small conferences may be part of the plan. New analyses of extant data sets and development or use of new methodologies or approaches may also be proposed.

Each exploratory grant should also present a description of the anticipated longer-term goals of the collaboration as it develops into an application for an R01 research grant with capacity building and training built in. As one outcome of the work under the R21 grant, grantees will be expected to provide a detailed assessment of the specific research issues and capacity-building and training needs in the developing country that the proposed follow-up R01 or other future application will address. The relevance of the focus of the proposed research to the health of the host endemic country should be justified. The assessment may include, but is not limited to, needed skills and expertise in laboratory, clinical, epidemiological, and social science research. In addition, the involvement, if any, of the developing country institution and faculty in formulating treatment and prevention policies locally, nationally, regionally, or internationally should be noted.

The applicants will also initiate development of needed resources and infrastructure. Research training in the context of the proposed research may take place at any of the collaborating sites and may vary, depending on the strengths of the particular investigators and institutions that apply and the need to build capacity to support research and future interventions. However, any research at the high-income site must also involve training for participating low-to middle-income investigators, and more than 50% of the proposed research must be conducted at the low- to middle-income country site(s).

Relevant research for the R21 and follow-up applications may range from basic science to epidemiological, translational, clinical, operational, and health services research that is culturally appropriate, feasible, and acceptable for implementation within the foreign site. Relevant research topics should be related to neurodevelopmental disabilities and neurological disorders, including cognitive, motor, sensory, and behavioral impairment from birth to advanced age. Examples include mental retardation, seizure disorders such as epilepsy, movement disorders such as Parkinson disease, and dementias (including those related to age and those caused by HIV, malaria, or other infection). …

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