Academic journal article Environmental Health Perspectives

Genetic Susceptibility: A Higher Risk of Congestive Heart Failure in Blacks: Genetics May Be Responsible. (Headliners: NIEHS-Supported Research)

Academic journal article Environmental Health Perspectives

Genetic Susceptibility: A Higher Risk of Congestive Heart Failure in Blacks: Genetics May Be Responsible. (Headliners: NIEHS-Supported Research)

Article excerpt

Small KM, Wagoner LE, Levin AM, Kardia SLR, Liggett SB. 2002. Synergistic polymorphisms of [[beta].sub.1] and [[alpha].sub.2c]-adrenergic receptors and the risk of congestive heart failure. N Engl J Med 347(15):1135-1142.

Congestive heart failure (CHF) is one of the leading causes of death in the United States: nearly 5 million people suffer from the most common forms of heart failure (idiopathic and ischemic), and about half of CHF patients die within five years. Predicting who in the general population or among those with some preexisting cardiac disease will develop CHF has been an elusive goal. However, racial differences in the incidence and progression of CHF and its response to therapy suggest that a genetic component is at play.

Two receptors--the presynaptic [[alpha].sub.2c]-adrenergic receptor and the postsynaptic [[beta].sub.1]-adrenergic receptor--work together to control the release of norepinephrine and the resulting force of the heart muscle contraction. Polymorphic variations in these receptors that increase the release of norepinephrine could result in more forceful heart contractions over a period of years, leading to more heart failure. NIEHS grantee Stephen B. Liggett, of the University of Cincinnati College of Medicine and Howard Hughes Medical Institute, and colleagues investigated the incidence of these polymorphisms in a group of 348 black and white subjects who were either healthy or had heart failure. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.