Academic journal article Research Quarterly for Exercise and Sport

Homocysteine and Vascular Access Thrombosis in End-Stage Renal Disease Patients: A Retrospective Study. (Health)

Academic journal article Research Quarterly for Exercise and Sport

Homocysteine and Vascular Access Thrombosis in End-Stage Renal Disease Patients: A Retrospective Study. (Health)

Article excerpt

One of the most important aspects for successful maintenance of hemodialysis in end-stage renal disease (ESRD) patients is the integrity of the vascular access. Access dysfunction due to thrombosis is the most common cause of hospitalization among maintenance hemodialysis patients. This dysfunction or thrombosis is a major prevalent clinical problem accounting for an average of 17% of hemodialysis patient admissions in one study with $500 million to $1.3 billion spent each year in the United States to maintain a viable vascular access and control serious morbidity. Little is understood about risk factors associated with vascular access thrombosis (VAT) with the problem being described as "ill defined." Although pathology in End-Stage Renal Disease (ESRD) patients with high total homocysteine (tHcy) can be established, the research findings with vascular access thrombosis (VAT) and tHcy are equivocal. Investigators have found significantly higher homocysteine levels in patients with recurrent VAT compared with one or less episodes of thrombosis. Initial prospective evidence supports an independent association between tHcy levels and access thrombosis. The purpose of this study was to determine if significant associations exist between tHcy, age, gender, previous morbidity (diabetes and hypertension) and the number of vascular access thromboses in patients with ESRD. …

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