Academic journal article Ethics & Medicine

Pharmacogenetics, 2nd Edition

Academic journal article Ethics & Medicine

Pharmacogenetics, 2nd Edition

Article excerpt

Pharmacogenetics, 2nd edition Wendell W. Weber. Oxford: Oxford University Press, 2008. ISBN 978-0-19-534151-5; 433 PAGES, CLOTH, $79.50

Doctors prescribe drugs to patients with an expected therapeutic end in mind. However, due to the variety of human responses to different drugs, drug therapy is a medical art. In Pharmacogenetics , Dr. Wendell Weber provides a significant update to his first edition, which appeared in 1997.

Weber divides the book into four sections: Foundations, Fundamentals, Futures, and Synthesis. "Foundations" explains the origin of the field and its defining features. Spanning two chapters, it provides a brief history and definition of pharmacogenetics. "Fundamentals" focuses on the principles of the field. The bulk of the book, this section includes seven chapters focusing on various topics, such as human drug response, age-related and ethnic issues in pharmacology, and strategies for modeling human drug response. "Futures" proposes the prospects of pharmacogenetics by discussing drug discovery and predictive biology. This explains the genetic pathways to improve drug therapy and the possibility of personalized medicine. Finally, in the brief "Synthesis" section, Weber finishes his work with a very short overview of the field. …

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