Academic journal article Genetic Counseling

Cytogenetic Study in Recurrent Pregnancy Loss: An Experience from Tertiary Care Centre

Academic journal article Genetic Counseling

Cytogenetic Study in Recurrent Pregnancy Loss: An Experience from Tertiary Care Centre

Article excerpt

Chromosomal aberration is the most common cause for recurrent pregnancy loss (2). The objective of our study was to look for the prevalence of chromosomal abnormalities in cases of recurrent pregnancy loss. Chromosomal analysis was performed on blood samples from two hundred and ten couples with recurrent pregnancy loss using GTG banding as part of the cytogenetic investigation. Chromosomal aberrations were found in 36 (8.57%) patients (4) as shown in table 1. The chromosomal abnormalities (3) were as follows: Numerical abnormalities (0.95%), Structural abnormalities - translocations (2.4%), Inversions (0.47%), and Polymorphic variants (4.76%). The seven new balanced translocations viz., 46,XX,t(4;6)(pl2;p24), 46,XX,t(4;21)(q22;q21), 46,XX,t(l;3)(p32;q27),46,XX,t(5;6)(pl5;q25),46Ät(10;14Xq24;q32), 46rXX,t(10;22)(q24;ql4), and46^?CX,t(7;20Xpl5;ql3.3) detected in these patients with recurrent pregnancy loss, have not been reported elsewhere in the literature. Preconception genetic counseling including karyotype is a prerequisite to identify risk factors in couples with recurrent pregnancy loss (1). Genetic services for a couple provide information regarding diagnosis, early detection, treatment, recurrence risks and support services.

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