Academic journal article Iranian Journal of Public Health

Identification of Mutation of Glucose-6-Phosphate Dehydrogenase (G6PD) in Iran: Meta- Analysis Study

Academic journal article Iranian Journal of Public Health

Identification of Mutation of Glucose-6-Phosphate Dehydrogenase (G6PD) in Iran: Meta- Analysis Study

Article excerpt

Abstract

Background: Glucose-6-phosphate dehydrogenase is one of the most common genetic deficiencies, which approximately 400 million people in the world suffer from. According to authors' initial search, numerous studies have been carried out in Iran regarding molecular variants of this enzyme. Thus, this meta-analysis presented a reliable estimation about prevalence of different types of molecular mutations of G6PD Enzyme in Iran.

Methods: Keywords "glucose 6 phosphate dehydrogenase or G6PD, Mediterranean or Chatham or Cosenza and mutation, Iran or Iranian and their Persian equivalents" were searched in different databases. Moreover, reference list of the published studies were examined to increase sensitivity and to select more studies. After studying titles and abstracts of retrieved articles, excluding the repeated and unrelated ones, and evaluating quality of articles, documents were selected. Data was analyzed using STATA.

Results: After performing systematic review, 22 papers were entered this meta-analysis and 1698 subjects were examined concerning G6PD molecular mutation. In this meta-analysis, prevalence of Mediterranean mutation, Chatham mutation and Cosenza mutation in Iran was estimated 78.2%, 9.1% and 0.5% respectively.

Conclusions: This meta-analysis showed that in spite of prevalence of different types of G6PD molecular mutations in center, north, north-west and west of Iran, the most common molecular mutations in people with G6PD deficiency in Iran, like other Mediterranean countries and countries around Persian Gulf, were Mediterranean mutation, Chatham mutation and Cosenza mutation. It is also recommended that future studies may focus on races and regions which haven't been taken into consideration up to now.

Keywords: G6PD, Mediterranean, Chatham, Cosenza, Mutation, Iran

Introduction

G6PD (Glucose-6-phosphate dehydrogenase) is one of the most important body enzymes which exists in different cells like red blood cells (1-2). G6PD deficiency is one of the most prevalent ge- netic deficiencies, which approximately 400 mil- lion people in the world suffer from. G6PD defi- ciency can result in problems such as mental retardation, renal failure, infant jaundice, liver dis- eases and chronic anemia. Children or adults with this deficiency will experience severe life-threaten- ing hemolytic attacks in a case they use some materials including Anti-malaria drugs, oxidative materials or fava bean (1-4).

G6PD deficiency varies in terms of variation and spread (3). Approximately, 7.5% of people around the world carry one or two deficient G6PD genes (1). In studies carried out in this regard, preva- lence of G6PD deficiency in Pakistan, UAE, Saudi Arabia, Kuwait, Bahrain, Oman, Egypt and Iran was 2-8, 11, 2-26, 19, 21, 27, 1 and 11.5% respectively(4, 5). Also, its prevalence varies in different areas of Iran. For example, its prevalence was 3.2 in 2501 screened infants in Esfahan (cen- tre of Iran) (6) and 2.1% in Zanjan (Center and North West of Iran) (7).

Previous researches on prevalence of G6PD molecular variants reveals that Mediterranean, Chatham and Cosenza mutations are the most common mutations in Iran with the highest fre- quency attributable to Mediterranean mutation (1). Prevalence of Mediterranean and Chatham muta- tion were 86.4 and 9.71% respectively in Gilan (5, 8). Moreover, Mediterranean mutation prevalence was reported 91.2% and 66.2% in Kurdish (West of Iran) (9) and Mazandaran (North of Iran) (5, 8). Preliminary electronic search in addition to researchers professional experiences reflect the fact that several studies have been carried out on determining molecular mutation of G6PD and each of them has reported different level of these mutations. However, researchers are still using similar designs and methodology which impose huge financial and non-financial burden; if we can present a more convincing and acceptable estima- tion from the results of previous studies, a new strategy and process may be used in future re- search. …

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