Academic journal article Iranian Journal of Public Health

In-Silico Investigation of Mir-222 in H. Pylori-Associated Gastric Cancer

Academic journal article Iranian Journal of Public Health

In-Silico Investigation of Mir-222 in H. Pylori-Associated Gastric Cancer

Article excerpt

Background: Little is known about the potential role of miRNAs in the carcinogenesis of gastric cancer induced by H. pylori. Bioinformatics databases were used to determine possible molecular functions and pathways of miR-222 as a proposed prognostic biomarker in gastric cancer.

Methods: MiR-222 targetome including validated and pre- dicted targets were evaluated by miRTarBase and miRWalk databases. Expression of all miR-222 target genes was ana- lyzed in both normal and tumor gastric cells using UniGene database. Finally, normal and tumor gastric expressing tar- getome of miR-222 were assessed in DAVID database for enrichment analysis of molecular pathways.

Results: DAVID database outcomes demonstrated that mul- tiple KEGG signaling pathways including pathways in can- cer, in gap junction and tight junction and in chemokine sig- naling pathway are the most engaged pathways induced by miR-222 targetome. …

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