Academic journal article Iranian Journal of Public Health

CHARACTERIZATION OF OVERT AND OCCULT HEPATITIS B VIRUS INFECTION AMONG HTLV-1 POSITIVE HEALTHY CARRIERS IN THE NORTHEAST OF Iran; AN HTLV-I ENDEMIC AREA

Academic journal article Iranian Journal of Public Health

CHARACTERIZATION OF OVERT AND OCCULT HEPATITIS B VIRUS INFECTION AMONG HTLV-1 POSITIVE HEALTHY CARRIERS IN THE NORTHEAST OF Iran; AN HTLV-I ENDEMIC AREA

Article excerpt

Background: To date, no studies have provided data on hepatitis B virus (HBV) prevalence among asymptomatic, healthy human T-lymphotropic virus (HTLV-I) positive car- riers. This sero- and molecular epidemiology study was per- formed on patients in the Northeast of Iran, which is an en- demic area for HTLv-I infection.

Methods: 109 sera were collected from HTLV-I positive healthy carriers who were admitted to Ghaem Hospital, Mashhad City. All were tested for HBV serology and subse- quently, real time PCR was carried out on the samples, re- gardless of the results of the serology. Standard PCR and direct sequencing were applied on positive samples.

Results: All cases were negative for HBsAg. Anti-HBc and anti-HBs were positive in 34 (31.1%), and 35 (32%) individu- als, respectively. There were 19 (17.4%) cases that were posi- tive only for anti-HBs, and they had already received HBV vaccine, 16 (15%) were positive for both anti-HBs and anti- HBc, indicating a past-resolved HBV infection, 18 (16.5%) were isolated as anti-HBc, and 56 (51.34%) were negative for all HBV serological markers. …

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