Academic journal article Iranian Journal of Public Health

FREQUENCY OF ADHESIVE VIRULENCE FACTORS IN CARBAPENEMASE-PRODUCING ACINETOBACTER BAUMANNII ISOLATED FROM CLINICAL SAMPLES IN WEST OF Iran

Academic journal article Iranian Journal of Public Health

FREQUENCY OF ADHESIVE VIRULENCE FACTORS IN CARBAPENEMASE-PRODUCING ACINETOBACTER BAUMANNII ISOLATED FROM CLINICAL SAMPLES IN WEST OF Iran

Article excerpt

Background: Acinetobacter baumannii is a significant oppor- tunistic pathogen which causes severe infections related to catheters and ventilator. Adhesive virulence factors (VFs) are effective in A. baumannii adherence and pathogenicity. The aim of this study is to evaluate the frequency of adhesive virulence factors in carbapenemase-producing A.baumannii .

Methods: In total, 104 A. baumannii were collected from teaching hospitals of Kermanshah, Iran within March 2011 to March 2013. All the isolates were tested for antimicrobial susceptibility by Kirby-Bauer disk diffusion method. Car- bapenemase-producing isolates were identified, DNA of iso- lates was extracted by boiling and it was investigated for the presence of adhesive virulence factors by PCR.

Results: Among 50 carbapenemase-producing isolates, the frequency of fimH and csgA genes was found to be 30(60%) and 27(54%), respectively. 20 isolates (40%) carried both of fimH and csgA genes, but 13(26%) carried none of these two genes. None of these isolates presented genes codifying for other different adhesive virulence factors include fimbriae Dr (afa/draBC), fimbriae S (sfa/focDE), fimbriae P (pap), cap- sule (kpsMT), fibronecting receptor (fnb). …

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