Academic journal article Iranian Journal of Public Health

Design and Synthesis of Novel Diphenylurea Derivatives with Antimicrobial and Antifungal Potential

Academic journal article Iranian Journal of Public Health

Design and Synthesis of Novel Diphenylurea Derivatives with Antimicrobial and Antifungal Potential

Article excerpt

Background: As regards the halogen, atoms in the pharma- cophore structure can be beneficial for antimicrobial activity; therefore, chloro derivatives were chosen to synthesize our target compounds. In view of these observations, we have designed new compounds incorporating with the above pharmacophores together in order to prepare molecules hav- ing enhanced antimicrobial and antifungal activity. Therefore, we synthesized new compounds containing urea groups in order to investigate their antibacterial and antifungal activi- ties.

Methods: 4-amino phenyl ethyl ester 1 as a base compound was available. 4-amino phenyl hydrazide 2 was prepared by reaction of hydrazine hydrate with compound 1. 4-amino phenyl hydrazone 6, 7 was prepared by reaction of com- pound 2 with 3-chlorobenzaldehyde and 4- chlorobenzaldehyde. Target compounds were synthesized by the reaction of compound 6, 7 with corresponding isocyanat.

Results: Thin layer chromatography was used to determine the purity of the compounds synthesized. …

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