Academic journal article Iranian Journal of Public Health

Resistance to Erythromycin and Clindamycin of Staphylococcus Aureus Isolates from Sanandajian Patients

Academic journal article Iranian Journal of Public Health

Resistance to Erythromycin and Clindamycin of Staphylococcus Aureus Isolates from Sanandajian Patients

Article excerpt

Background: Staphylococcus aureus successfully colonizes in humans, contaminates the hospital environment, and has the genetic versatility to acquire resistance to multiple antimicro- bial agents. This study was done to determine the prevalence and genetic basis of erythromycin and clindamycin resistance in Staphylococcus aureus isolates from Sanandajian patients.

Methods: One hundred and fifty clinical isolates of S. aureus were collected from Sanandaj Hospital. Susceptibility to anti- biotics (erythromycin and clindamycin) was determined by disk agar diffusion method with minimum inhibitory concen- tration (MIC) evaluated on Muller-Hinton agar as described by the Clinical and Laboratory Standards Institute (CLSI). The strains Staphylococcus aureus were screened by polymerase chain reaction (PCR) for the presence of five common eryth- romycin and clindamycin genes resistance determinants, which were respectively ermA, ermB, ermC, mphC, msrA.

Results: Using DAD method, 54. …

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