Academic journal article Iranian Journal of Public Health

Prevalence of Fluoroquinolone-Resistance among Extended-Spectrum B Lactamase Producing Klebsiella Isolates from Clinical Specimens

Academic journal article Iranian Journal of Public Health

Prevalence of Fluoroquinolone-Resistance among Extended-Spectrum B Lactamase Producing Klebsiella Isolates from Clinical Specimens

Article excerpt

Background: Klebsiella pneumonia is one of the most common causes of nosocomial infections causinghigh rate of mortality. However, most isolates of Klebsiella pneumoniae are multidrug resistant and increasing the emergence of ESBL-mediated resistance among hospital isolates. Also because ESBL- producing Klebsiella pneumoniae are frequently resistant to fluo- roquinolone, treatment options for treatment of infections caused by these bacteria are limited. The aim of this study was to determine the prevalence of fluoroquinolone- resistance among Extended-Spectrum β-Lactamase produc- ing Klebsiella isolates from clinical specimens referred to Sha- hid Beheshti hospital in Kashan.

Methods: A cross-sectional study was conducted between April 1, 2013, and April 17, 2014. 121 non-repetitive clinical isolates suspected of Klebsiella from patients referred to Sha- hid Beheshti hospital in Kashan, were enrolled in the study. Antimicrobial resistance profile and detection of quinolone resistance were determined using disk diffusion method ac- cording to the Clinical and Laboratory Standards Institute. Double disk synergy test was performed to confirm the pro- duction of Extended-Spectrum β-Lactamases (ESBLs). ESBLs-producing Klebsiella showed to be resistant to fluoro- quinolone was investigated using the disk diffusion method and the double-disk synergism test. …

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