Academic journal article Iranian Journal of Public Health

PLASMID-MEDIATED QUINOLONE RESISTANCE DETERMINANTS AMONG ENTEROBACTER CLOACAE ISOLATED FROM HOSPITALS OF QAZVIN, Iran

Academic journal article Iranian Journal of Public Health

PLASMID-MEDIATED QUINOLONE RESISTANCE DETERMINANTS AMONG ENTEROBACTER CLOACAE ISOLATED FROM HOSPITALS OF QAZVIN, Iran

Article excerpt

Background: Plasmid-mediated quinolone resistance is the new mechanism of quinolone resistance, which has been reported in several parts of the world. Three major groups of qnr determinants, qnrA, qnrB, and qnrS, are increasingly being identified in clinical isolates of various enterobacterial species. The main aim of this study was to determine the frequency of qnr genes among clinical isolates of E. cloacae collected from Qazvin hospitals.

Methods: A total of 96 nalidixic acid non-susceptible E. cloacae isolates were obtained from different clinical samples. Antimicrobial susceptibility was determined by standard Kir- by-Bauer disk diffusion method. PCR and sequencing were employed to detect qnrA, qnrB, and qnrS genes using the specific primers.

Results: In total, qnr-encoding genes were present in 56 (58.3%) nalidixic acid non-susceptible isolates of which qnrB1 (36-45%) was the most common gene followed by qnrS1 (22-27. …

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