Academic journal article Iranian Journal of Public Health

Klebsiella Pneumoniae, B-Lactamases, 16s Rrna Methylase, Arma, Blactx-M-15

Academic journal article Iranian Journal of Public Health

Klebsiella Pneumoniae, B-Lactamases, 16s Rrna Methylase, Arma, Blactx-M-15

Article excerpt

Background: The emergence of antibacterial resistance and ESBL-producing Escherichia coli recovered from urinary tract infections (UTI) areknown as important health problems in different regions, therefore therapeutic options for these in- fections are limited.The aim of this study was the detection of blaTEM, blaSHV and blaCTX-M genesamong Escherichia coli strains isolated from Children Medical Center hospital, Tehran, Iran.

Methods: This study was conducted on 100 Escherichia coli isolates from urine specimens of patients with UTI who re- ferred to Children Medical Center, Tehran, Iran from No- vember 2012 and July 2013. Antibiotic susceptibility test was performed by Kirby-Bauer disc diffusion method according to CLSI guidelines. The blaCTX-M, blaTEMandblaSH- Vgeneswere detected by PCR and sequencing methods.

Results: The resistance rate of isolates toGentami- cin,Imipenem, Nitrofurantoin,Cefotaxime, Ceftazidime, Amikacin, Cefepime, Piperacillin/Tazobactam, Co- trimoxazole,Cefixime andCephalothin, were 25 (25%),0 (0%), 7 (7%), 51(51%), 24(24%), 2 (2%),6 (6%),2 (2%),79 (79%),36 (36%) and 43 (43%)respectively. …

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