Academic journal article Iranian Journal of Public Health

THE FIRST REPORT OF THE QNR, AAC(6')-IB-CR AND QEPA GENES IN QUINOLONE RESISTANT ESCHERICHIA COLI AND KLEBSIELLAPNEUMONIAE IN Iran

Academic journal article Iranian Journal of Public Health

THE FIRST REPORT OF THE QNR, AAC(6')-IB-CR AND QEPA GENES IN QUINOLONE RESISTANT ESCHERICHIA COLI AND KLEBSIELLAPNEUMONIAE IN Iran

Article excerpt

Background: This study therefore was designed to charac- terize the prevalence of plasmid-mediated quinolone re- sistance (PMQR) determinants qnr, aac(6?)-Ib-cr and qepA among quinolone resistant of Escherichia coli and Klebsiella pneumoniae.

Methods: One hundred and thirty-four quinolone resistance isolates were collected during nine months. ESBL production was determined by the Clinical and Laboratory Standards Institute (CLSI) ESBL confirmatory test. MICs of two anti- microbial agents were determined by E-test and screening for the qnrA, qnrB, qnrS, aac(6?)-Ib-cr and qep A genes was car- ried out by PCR amplification.

Results: Of 134 quinolone resistnce isolates, 69.4% (n= 93) were able to produce ESBL (66.1% of E. coli and 73% of K.pneumoniae). The PMQR gene qnrA, qnrB and qnrS were found in 5.3% (n= 5), 14.9% (n= 14) and 13.8% (n= 13) of isolates respectively. Most of the qnr positive strains were ESBL producers. Sixty-six (49.3%) isolates were positive for aac(6?)-Ib -cr that 54. …

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