Academic journal article Iranian Journal of Public Health

The Relation between Density of Helicobacter Pylori in Biopsy with Serum Level of Metalloporoteinase in Infected Patients

Academic journal article Iranian Journal of Public Health

The Relation between Density of Helicobacter Pylori in Biopsy with Serum Level of Metalloporoteinase in Infected Patients

Article excerpt

Background: This study determines the relationship be- tween H.pylori density in biopsy and concentration of mmp-3 in serum.

Methods: The study was performed on 217 patients (20-80 years) both sexes, with dyspepsia symptoms referred to Hajar hospital in Shahrekord. Demographic data were recorded, such as age and sex. Blood sampling were done and the se- rum was separated immediately and stored at -70 degree of centigrade until measuring the concentration of mmp-3 in serum by ELISA methods. Patient's biopsies were checked by 16sRNA and glm genes by polymerase chain reaction for H. pylori. Density of H.pyloriwas graded according to the number of HP bacteria counted in light microscopy by (x1000 magnified).

Results: We observed that 69.12% of patients (150 of 217) were positive for H. pylori, and 30.87% were negative (67 of 217). In the positive patients, 46% were male and 54% were female; also in the negative patients, 41% were male and 59% were female. …

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