Academic journal article Iranian Journal of Public Health

Frequency of Helicobacter Pylori and Presence of Bab B Gene in Positive Samples of Hajar Hospital Patients in Shahrekord

Academic journal article Iranian Journal of Public Health

Frequency of Helicobacter Pylori and Presence of Bab B Gene in Positive Samples of Hajar Hospital Patients in Shahrekord

Article excerpt

Background: The aim of this study is to determine the fre- quency of Helicobacter pylori and bab B gene in patients of Shahrekord.

Methods: In this descriptive study, demographic data were recorded from 230 patients with gastrointestinal disorders who were referred to the endoscopy ward Hajar hospital of Shahrekord for upper endoscopy. one gastric biopsy sample of antrum were taken, Patient's biopsies were checked by rapid urease test (RUT) and by polymerase chain reaction (PCR) of 16srna.In the laboratory DNA was extracted, using bioflux tissue kit and examined for bab B genes by PCR.

Results: Among 230 patients (mean age 44 years); there were 109(47.4%) men and 121(52.6%) female. RUT and 16srna was examined for samples, 102(44.3) samples were positive for RUT and 16sRNA gene evaluation, and 128(55.7%) were negative for Helicobacter pylori. Bab B gene was examined for positive samples (infected patients), and 77(75.49%) were positive, (p<0.001).

Conclusion: Our results showed that the frequency of Heli- cobacter pylori is lower than 50% in Shahrekord and it can be related to genetic, host factors, environment and virulence factors of bacterium in Shahrekord, and Helicobacter pylori strains with bab B are common in patients of Shahrekord. …

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