Academic journal article Iranian Journal of Public Health

RELEVANCE OF HELICOBACTER PYLORI CAGA STATUS AND GENOTYPES OF VACA GENE TO PEPTIC ULCER DISEASE (PUD) IN Iran

Academic journal article Iranian Journal of Public Health

RELEVANCE OF HELICOBACTER PYLORI CAGA STATUS AND GENOTYPES OF VACA GENE TO PEPTIC ULCER DISEASE (PUD) IN Iran

Article excerpt

Background: Helicobacter pylori (H. pylori) is the main cause of peptic ulcer disease (PUD) and gastric adenocarcinoma. There is a close relationship between H. pylori -specific factors and different gastroduodenal diseases. The aim of present study was to clarify the roles of the H. pylori vacA-s, -m, -i, and -d regions, and H. pylori cagA status in relation to PUD risk.

Methods: A total of 171 H. pylori isolates from ten districts in Iran were used for genotyping.

Results: The subjects included 114/171 with non-atrophic gastritis (NAG) and 57/171 with PUD. The frequency of vacA s1 was 92.4%, s2 8.8%, m1 26.3%, m2 73.7%, i1 43.3%, i2 57.3%, d1 40.9%, d2 59.1%, and cagA 67.8%. Statistical analysis showed that frequency of the vacA i1 and cagA gen- otypes in patients with PUD (58.6% and 81. …

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