Academic journal article Iranian Journal of Public Health

Relevance of Helicobacter Pylori Vaca 3'-End Region Polymorphism to Gastric Cancer

Academic journal article Iranian Journal of Public Health

Relevance of Helicobacter Pylori Vaca 3'-End Region Polymorphism to Gastric Cancer

Article excerpt

Background: Significance of the 3'-end region polymor- phisms (denoted c1/c2-c2: no deletion) of Helicobacter pylori vacA gene in determining risk of gastroduodenal diseases has still not been understood. The aim of present study was to analyze the relationship between H. pylori vacA 3'-end region polymorphism (c1/-c2) and risk gastric cancer (GC).

Methods: A total of 160 H. pylori isolates from different re- gions of Iran were recruited and genotyped. Data were col- lected and analyzed using SPSS version 19.

Results: The subjects included 114/160 with non-atrophic gastritis (NAG) and 46/160 with GC. The frequency of vacA s1 was 84.4%, s2 11.3%, m1 32.5%, m2 67.5%, i1 48.1%, i2 56.3%, d1 44.4%, d2 54.4%, c1 41.3, c2 65.6, and cagA 66.9%. Statistical analysis showed that frequency of the vacA m1, vacA i1, vacA d1, vacA c1, and cagA genotypes in pa- tients whit GC (54.3%, 80.4%, 65.9%, 84.8%, and 82.2%, respectively) was higher than in those with NAG (23. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.