Academic journal article Iranian Journal of Public Health

Antagonistic Activity of Lactobacillus Strains Isolated from Fecal Microflora of Healthy Breast-Fed Infants against Shigella Flexneri

Academic journal article Iranian Journal of Public Health

Antagonistic Activity of Lactobacillus Strains Isolated from Fecal Microflora of Healthy Breast-Fed Infants against Shigella Flexneri

Article excerpt

Background: Shigella £exneri is a Gram-negative facultatively intracellular pathogen responsible for bacillary dysentery in humans. More than one million deaths occur yearly due to infections with Shigella spp. and the victims are mostly chil- dren of the developing world. The aim of this study was to investigate antagonistic activity of Lactobacillus strains isolated from fecal microflora of healthy breast-fed infants against Shigella flexneri.

Methods: Fecal samples were collected from 90 healthy breast-fed infants younger than 18 months and cultured on MRS agar under anaerobic condition. Lactobacillus strains were identified with phenotypic and biochemical tests. Then probiotic potential of isolated strains was evaluated in MRS broth with pH 2.5 and oxbile 3%. Finally antagonistic activity of Lactobacillus strains with probiotic potential evaluated against Shigella flexneri ATCC 12022 by well diffusion method. …

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