Academic journal article Iranian Journal of Public Health

Antimicrobial Effect of Statins Is Suppressed by Cholesterol

Academic journal article Iranian Journal of Public Health

Antimicrobial Effect of Statins Is Suppressed by Cholesterol

Article excerpt

Background: Isoprenoid biosynthesis is a key metabolic pathway producing a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membrane. In the other hand it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agent may have direct antimicrobial effect on some bacteria. The exact action of statins in microbial metabolism is not clearly understood. It is possible that statins inhibit synthesis or utilization of some sterol precursor, which is necessary for bacterial membrane integrity.In order to test if statins inhibit the production of a compound, which can be used in mem- brane, cholesterol, would replace it and rescue bacteria from toxic effect of statins.

Methods: To examine that possibility, we assessed the anti- bacterial effect of statins with different classes; lovastatin, simvastatin and atorvastatin, alone and in combination with cholesterol on two gram-positive ( Staphylococcus aureus and Enterococcus faecalis) and two gram-negative (Pseudomonas aeru- ginosa and Escherichia coli) bacteria using gel diffusion assay. …

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