Academic journal article Iranian Journal of Public Health

Antifungal Activity of Total Extract and Chloroform, Methanol and Aqueous Fractions of Aerial Parts of Nepeta Depauperata against 5 Fungal Strains

Academic journal article Iranian Journal of Public Health

Antifungal Activity of Total Extract and Chloroform, Methanol and Aqueous Fractions of Aerial Parts of Nepeta Depauperata against 5 Fungal Strains

Article excerpt

Background: Increased consumption of synthetic antifungal compounds has created serious side effects and wide spread antifungal resistance. We report the results of evaluation of antifungal properties of different crude extract and relevant fraction of aerial parts of Nepeta depauperata.

Methods: Extracts and fractions were obtained according to maceration standard methods. The crude extract and fractions were diluted in different values from 400 to 25 mg/ml. Candida albicans(ATCC 10231), Aspergillus niger (PTCC 5010), Aspergillus flavus (PTCC 5004), Aspergillus fumigatus (PTCC 5009), fusarium oxysporium (PFCC 38-115), were used to assay the antifungal activity by disc diffusion method. The drug ketoconazole was used as a control for lack of growth in order to comparing it as a chemical drug with the mentioned extract and fractions. MIC values were determined using micro- dilution method according to CLSI. …

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