Academic journal article Iranian Journal of Public Health

Evaluation of Antibacterial Effect of Alginate Poly Amidoamine (Pamam) Dendrimers Nanocomposites G2 "A In-Vivo Study"

Academic journal article Iranian Journal of Public Health

Evaluation of Antibacterial Effect of Alginate Poly Amidoamine (Pamam) Dendrimers Nanocomposites G2 "A In-Vivo Study"

Article excerpt

Background: Aim of this study was survey on antibacterial activity of Alginate (PAMAM) dendrimer nanocomposite G2 on S. typhimurium.

Methods: In this study 45 mice in 3 grups (15 Control non infected mice S. typhimurium, 15 infected mice by S. typhimuri- um without treatment by alginate PAMAM dendrimer nano- composite G2 and 15 infected mice by S. typhimurium with treatment by alginate PAMAM dendrimer nanocomposite G2 in dose of 10 and 20 mg/kg) were used. Then about CFU 105 bacteria diluted with buffered phosphate by oral gavage needle was inoculated into mice. Then tissue damage was determined by light microscope.

Results: Based on the images, focal necrosis and accumula- tion of inflammatory cells in the necrotic area in liver cells were visible in infected mice. Also in infected mice by S. typhimurium that treated by alginate PAMAM dendrimer nanocomposite G2, accumulation of inflammatory cells and liver necrosis areas significantly reduced. …

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