Academic journal article Iranian Journal of Public Health

The Extent Application of Rnai for Treatment of Animal Viruses

Academic journal article Iranian Journal of Public Health

The Extent Application of Rnai for Treatment of Animal Viruses

Article excerpt

Background: RNA silencing or RNA interference (RNAi) is a conserved biological phenomenon that the small RNA- guided gene silencing ocuurs in a wide range of eukaryotic and Prokaryotic organisms and viruses. In recent years, pro- gress is being made in the development of RNA interference- based (RNAi-based) strategies for the control of gene expres- sion and RNAi has been widely exploited to silence gene expression. Both chemically synthesized siRNAs and pro- moter-dependent expressed shRNAs show potent gene- silencing activity in vitro and in vivo.

Methods: As part of this special issue on the biology, mech- anisms and applications of RNAi, we reviewed the recent advances on applying of RNAi in the development of nucleic acid-based technologies for therapeutic gene suppression against animal viral infections. …

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