Academic journal article Iranian Journal of Public Health

Molecular Identification of Nocardia Spp. Collected from Patients with Symptom Tuberculosis

Academic journal article Iranian Journal of Public Health

Molecular Identification of Nocardia Spp. Collected from Patients with Symptom Tuberculosis

Article excerpt

Background: The improved identification of isolates using molecular techniques have shown that the genus exhibits considerable taxonomic complexity and phenotypic base identification can be ambiguous. The aim of this study was to assess the species distribution of Nocardia strains mostly re- covered from patients suspected of having tuberculosis.

Methods: The clinical isolates were identified to species level using conventional tests and genotypic methods using single and multi locus sequence analysis (MLSA) of 16S rRNA, gyrB and secA1 genes.

Results: Nocardiosis was diagnosed in 46 patients. The most frequent underlying condition were organ transplantation (6 patients; 13%), cancer (6 patients; 13%), human immunodefi- ciency virus (HIV) (6 patients; 13%), non-infectious chronic lung disease (5 patients; 10.8%) and tuberculosis (4 patients; 8.7%). Nocardia species was recovered from 46 different clini- cal specimens, the most common of which was bronchoalve- olar lavage (BAL) (43. …

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