Academic journal article Iranian Journal of Public Health

ANTI-TUBERCULOSIS DRUG RESISTANCE IN WEST OF Iran

Academic journal article Iranian Journal of Public Health

ANTI-TUBERCULOSIS DRUG RESISTANCE IN WEST OF Iran

Article excerpt

Background: Mycobacterium tuberculosis has developed re- sistance to anti-tuberculosis drugs and becoming a major and alarming public health problem in worldwide. This study aimed to determine anti-tuberculosis drug resistance rate and to identify multidrug resistant tuberculosis (MDR-TB) in west of Iran.

Methods: Total of 130 samples were included Between De- cembers 2011 and July 2012 in the study from that 112 cases were Mycobacterium tuberculosis. The proportional method was carried out according to the CLSI on Lowenstein-Jensen against isoniazid, rifampcin, streptomycin, ethambutol, pyra- zinamide, para aminosalsilic acid, etionamid, cyclocerin. The microdillution method was carried out using 7H9 broth with 96 well-plates.

Results: From 112 isolates, resistance was observed to isoni- azid 18 (16.07%), rifampicin 16 (14.28%), streptomycin 25 (22.32%), ethambutol 15 (13.39%), pyrazinamide 27 (24.10%), para aminosalicylic acid 19 (16. …

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