Academic journal article Iranian Journal of Public Health

Detection of Aspergillosis in Immunocompromised Patients

Academic journal article Iranian Journal of Public Health

Detection of Aspergillosis in Immunocompromised Patients

Article excerpt

Background: Immunocompromised patients have been increasing in recent decades and Aspergillus species are the most frequent moulds have been isolated from immunocompromised patients. As the mortality rate is very high in these patients early detection and treatment is very crucial. In this study the incidence of aspergillosis was investigated in transplant patients by conventional and molecular methods.

Methods: In total 490 immunocompromised patients (liver and bone marrow transplant) were screened for aspergillosis by conventional and molecular methods. Clinical samples including: urine, sputum, fluids and tissue were examined by KOH smear, cultured on Sabouraud Dextrose Agar with Chloramphenicol, and incubated in room temperature for 14 days. Five ml blood of each patient was cultured using the BACTEC system and 1 ml serum of each patient was used for real-time Aspergillus PCR.

Results: The mean age of patients was 27 and 62% of patients were male. …

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