Academic journal article Iranian Journal of Public Health

ANTI-TRICHOMONAS VAGINALIS ACTIVITY OF THE FOENICULUM VULGARE FROM IranIAN SEMI-ARIED REGION

Academic journal article Iranian Journal of Public Health

ANTI-TRICHOMONAS VAGINALIS ACTIVITY OF THE FOENICULUM VULGARE FROM IranIAN SEMI-ARIED REGION

Article excerpt

Background: Trichomonas vaginalis is a parasitic protozoan with a predilection for human urogenital tract and causative agent for vaginitis, cervicitis and urethritis in females. The drug of choice for therapy is metronidazole however the main drawback to metronidazole is wide adverse effects and also there are evidence of emerging resistance. This study was aimed to determine the effect of Foeniculum vulgare on Trichomonas vaginalis isolated from a female patient with uro- genital complication.

Methods: Trichomonas vaginalis were cultured axenically in the TYM medium for 24-48 h. An initial inoculum of 1x 106 trophozoites/ml was achieved. The ethanolic extract of Foe- niculum vulgare was obtained and different concentrations of Foeniculum vulgare were performed (75 µg/ml, 150 µg /ml, 300 µg /ml, 600 µg /ml, 800 µg /ml). T. vaginalis were incu- bated with the mentioned concentrations of extracts for 24- 48 h along with positive and negative control. Positive and negative control was metronidazole (0.1 µg/ml) and culture medium, respectively. Experiments were performed in tripli- cate. …

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