Academic journal article Iranian Journal of Public Health

Evaluation of the Effect of Copper Oxide and Aluminum Oxide Nanoparticles on the Brucella Melitensis 16 M in Vitro

Academic journal article Iranian Journal of Public Health

Evaluation of the Effect of Copper Oxide and Aluminum Oxide Nanoparticles on the Brucella Melitensis 16 M in Vitro

Article excerpt

Background: Recently inorganic nanomaterials characterized with high level thermal stability and new physical and chemi- cal properties were considered for antimicrobial therapy. In the present study, the antibacterial activity of copper oxide and aluminum oxide nanoparticles was evaluated against Bru- cella melitensis 16M.

Methods: For the first stage, physical and chemical proper- ties of nanoparticles used in this study were checked and confirmed by means of double-beam ultraviolet-visible spec- trometer, X-Ray diffractometer underCuKα beam emission, and transmission electron microscope. Subsequently the min- imum inhibitory concentrations value (MICs) of nanoparti- cles was calculated using broth microdilution test. Time kill study was also performed to show the effect of antibacterial to inhibit the growth of Brucella by time. Eventually NCCLS disc diffusion method was carried out to investigate the effect of nanoparticles tested against Brucella melitensis 16 M.

Results: Our results showed that nanoparticles tested could be able to inhibit the growth of sessile Brucella cell. …

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