Academic journal article Iranian Journal of Public Health

Distribution of Ctx-M B-Lactamase Gene among Pseudomonas Aeruginosa Strains

Academic journal article Iranian Journal of Public Health

Distribution of Ctx-M B-Lactamase Gene among Pseudomonas Aeruginosa Strains

Article excerpt

Background: The production of Extended Spectrum Beta Lactamases (ESBLs) by P. aeruginosa is the main cause of re- sistance to Cephalosporins. In the past decade, CTX-M En- zymes have become the most prevalent ESBLs in Europe, Canada, and Asia.. In this study, the frequency of ESBL pro- ducing P. aeruginosa and molecular detection of the CTX-M gene was investigated.

Methods: In this study, a total of 33 clinical isolates P. aeru- ginosa were collected from patients hospitalized in Tehran. The isolates were identified using standard Biochemical tests. The resistance to ceftazidim was assessed by Kirby-Bauer disk diffusion method. The confirmatorytest for detection of resistant isolates wascarried out by double disk method at the presence of ceftazidim, cefepime and clavulanic acid. …

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