Academic journal article Iranian Journal of Public Health

FREQUENCY OF PER,VEB,SHV, TEM AND CTXM GENES IN RESISTANT STRAINS OF PSEUDOMONAS AERUGINOSA PRODUCING EXTENDED SPECTRUM [Beta]-LACTAMASES ISOLATED FROM CLINICAL SPECIMENS IN EDUCATIONAL HOSPITALS OF ZAHEDAN

Academic journal article Iranian Journal of Public Health

FREQUENCY OF PER,VEB,SHV, TEM AND CTXM GENES IN RESISTANT STRAINS OF PSEUDOMONAS AERUGINOSA PRODUCING EXTENDED SPECTRUM [Beta]-LACTAMASES ISOLATED FROM CLINICAL SPECIMENS IN EDUCATIONAL HOSPITALS OF ZAHEDAN

Article excerpt

Background: Pseudomonas aeruginosa is the most common pathogen causing nosocomial infections. Resistance of P. aeruginosa strains to the broad-spectrum cephalosporins may be mediated by the extended-spectrum b-lactamases (ESBLs). This study aimed to investigate the prevalence of ESBLs and antimicrobial susceptibilities of P. aeruginosa isolated from patients in Zahedan, Iran.

Methods: A total of 116 isolates of P. aeruginosa were col- lected during a year from teaching hospital in Zahedan, Iran. Susceptibility to nine antimicrobial agents was performed by disk diffusion method. ESBL producing strainswere detected by Combination disk test (CDT). In this study ESBL positive and other isolates showing MICs ≥ 4 µg/ml for ceftazidime, Cefotaxime, Ceftriaxone and Aztreonam were screened for the presence of the genes encoding bla(TEM), bla(SHV), bla(PER-1) and bla(VEB-1), genes by polymerase chain reac- tion.

Results: Ciprofloxacin and piperacillin were the most effec- tive anti-pseudomonal agents. …

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