Academic journal article International Journal of Child Health and Human Development

Outcome of Prenatal Pesticide Exposure

Academic journal article International Journal of Child Health and Human Development

Outcome of Prenatal Pesticide Exposure

Article excerpt

The developing brain is susceptible to adverse effects (AE) of environmental toxicants, including pesticides. The placenta is ineffective barrier against toxins, and the blood-brain barrier is incomplete. Experimental studies in rodents suggest that cholinesterase inhibitors can interfere with brain development causing permanent damage. Recent studies regarding outcomes of prenatal pesticide exposure were reviewed.

Fertility: Organo-chlorides and Organophosp hates (OP) were shown to decrease fertility, sperm count and viability.

Birth weight and head circumference: Prenatal exposure to OP was associated with decreased birth weight and head circumference.

Birth defects: Prenatal exposure to pesticides was associated with increased risk of orofacial clefts, hemangioma, musculoskeletal and nervous system defects, elevated risks of Neural Tube Defects (NTDs); anencephaly and spina bifida. Paternal exposure to Agent Orange (dioxin) was associated with an increased risk of birth defects, particularly NTDs.

Cancer: In a recent metanalysis exposures during pregnancy to unspecified residential pesticides insecticides and herbicides were positively associated with childhood leukemia. …

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