Academic journal article International Journal of Child Health and Human Development

Myasthenia and Child Development

Academic journal article International Journal of Child Health and Human Development

Myasthenia and Child Development

Article excerpt

Myasthenia is a rare under-diagnosed disease in childhood. Congenital myasthenic syndromes (CMS) are a heterogeneous group of disorders that may present initially with delay in developmental motor milestones.

Aim of the study: To evaluate the clinical characteristics and developmental aspects of children aged 3 months to 18 years from different ethnic origins diagnosed with myasthenia by clinical and electrophysiological studies and to correlate clinical findings with genetic workup and developmental outcomes.

Methods: Retrospective evaluation of 42 medical records of patients with myasthenia. The patients were sub-divided into 18 children with myasthenia gravis (MG) and 24 children with congenital myasthenic syndrome (CMS).

Results: Most of the children with MG were of Jewish origin and their mean age of symptoms onset was 10 years. Most of children categorized as CMS based on infantile age of onset, multiple affected siblings in the same family and seronegativity to acetyl choline receptors antibodies, were of Arab origin. Average age of onset was 11 months. …

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