Academic journal article International Journal of Child Health and Human Development

Functional Disconnectivities in Individuals with Autism Spectrum Disorders

Academic journal article International Journal of Child Health and Human Development

Functional Disconnectivities in Individuals with Autism Spectrum Disorders

Article excerpt

The neuropathology underlying autism spectrum and neurobehavioral disorders in general most consistently points to dysfunction in cortical-striatal pathways leading to inactivation, or insufficient engagement, of frontal and prefrontal lobes. By implication, there may be functional disconnection between the anterior and posterior higher cortical regions, instead of a fixed dysfunction in either one. Given this premise, reconnection of these systems via cognitive interventions constitutes a logical remedial approach in the treatment of adhd and neurobehavioral disorders through integrative cognitive and neuropsychological interventions. A fundamental understanding of the nature of functional disconnection syndromes informs a more comprehensive understanding of consciousness, awareness, awake and sleep states and their clinical impairments. Objectives was to outline the nature of functional disconnectivities in explaining cognitive neurologically compromised states. Methodology: coherence analysis of steady-state and event related eeg activity is compared in individuals with autistic spectrum disorders, persistent vegetative, minimally conscious, relaxed wakeful, and in attentive states. Results: all subjects demonstrated functional disconnectivities but autistic spectrum participants revealed underactive right and overactive left hemisphere activity. …

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