Academic journal article International Journal of Child Health and Human Development

Exploration of Resting Brain Connectivity Using Linear Coherence Measures in the Autistic Spectrum Disorder

Academic journal article International Journal of Child Health and Human Development

Exploration of Resting Brain Connectivity Using Linear Coherence Measures in the Autistic Spectrum Disorder

Article excerpt

Brain connectivity is considered one of the most promising fields in Neuroscience nowadays. In the Autistic Spectrum Disorder (ASD) it has been emphasized that distorted brain connectivity is the main path-physiologic background in the ASD syndrome. Nonetheless, reports are controversial and methodological approaches are too different. We studied a group of 14 right-handed autistic patients with age 70.3±29.32 (months) and 14 healthy subjects (66.68±29.6) with IQs over 85. EEG was digitally recorded with a frequency sample of 200 Hz. All recordings were performed with the subjects lying in a in a recumbent position, in eye-opened condition; EEG electrodes were attached to the scalp according to the 10-20 System Linear magnitude squared coherence was calculated for a set of EEG records considering hemispheric and inter-hemispheric as the main factors. Inter-hemispheric measures were settled as the homologous right-leftleads (i.e. C3-C4, T3-T5, etc.) and intra-hemispheric were defined as longrange and short-range EEG leads organized in a sagital frontal-occipital pattern. We also considered transversal anterior and posterior leads groups. An ANOVA test was carried out considering a between factor "Group" and two within factors (repeated measures) "sagital areas" and "Hemisphere". Interhemispheric coherence values were significantly higher in the ASD group, considering the sagittal areas. …

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