Academic journal article International Journal of Child Health and Human Development

Trabecular Bone Score and Frax in Ukrainian Normal Women

Academic journal article International Journal of Child Health and Human Development

Trabecular Bone Score and Frax in Ukrainian Normal Women

Article excerpt

The aim of this study is evaluating trabecular bone score (TBS), fracture risk rate, assessed by FRAX, in normal women depending on duration of postmenopausal period (PMP) and presence of fracture (peripheral skeleton) in their anamnesis.

Materials and methods: We've examined 122 normal women aged 40-79 years (mean age - 56.2±0.8 yrs; mean height - 162.6±0.5 cm; mean weight - 71.5±1.3 kg), who were divided into the groups depending on presence of fracture of peripheral skeleton in their anamnesis: group A - without fractures (n=89, mean age - 55.9±0.9 yrs, mean height - 162.2±0.6 cm, mean weight - 72,1±1,5 kg) and group B - with fractures (n=33, mean age - 57.0±1.5 yrs, mean height - 163.5±0.6 cm, mean weight - 72.0±2.2 kg). The patients were also divided into the groups depending on duration of PMP: 1) without menopause (with normal menstrual cycle) (n=25), 2) 1-3 yrs (n=26), 3) 4-6 yrs (n=12), 4) 7-9 yrs (n=18), 5) 10-12 yrs (n=8), 6) 13-15 yrs (n=4), 7) 16-18 yrs (n=5), 8) more 19 yrs (n=7). Fracture risks were estimated using FRAX. TBS (L1-L4) was measured by DXA using a densitometer Prodigy, GE (TBS iNsight software package, Med-Imaps).

Results: We have not determined the significant difference of TBS between women without and with peripheral fractures in their anamnesis (group A - 1.271±0.02 mm-1, group B - 1.216±0.03 mm-1, F=3.2, p=0.07) and depending on duration of PMP (with normal menstrual cycle - group A - 1.370±0.02 mm- 1, group B - 1.333±0.04 mm-1, F=0.40; p=0.53; 1-3 yrs - group A - 1.311±0.03 mm-1, group B - 1.324±0.05 mm-1, F=0.05, p=0.83; 4-6 yrs - group A - 1. …

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