Academic journal article International Journal of Child Health and Human Development

Combination of Digital X-Ray Radiogrammetry and Frax® in Evaluation of Structural-Functional State of the Bone in Postmenopausal Women

Academic journal article International Journal of Child Health and Human Development

Combination of Digital X-Ray Radiogrammetry and Frax® in Evaluation of Structural-Functional State of the Bone in Postmenopausal Women

Article excerpt

The aim of the study was to estimate the informative value of digital X-ray radiogrammetry and its combination with FRAX® in evaluation of structuralfunctional state of bone in Ukrainian postmenopausal women.

Material and methods: 247 postmenopausal women aged 45-87 years were examined, average age 65±0.6 years, duration of postmenopausal period 16±1.6 years. Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometer (DXA) "Prodigy" and digital X-ray radiogrammetry (DXR) of the II-IV metacarpal bones. The ten years probability of hip fracture calculated with FRAX® tool.

Results: There is difference in distribution of bone indexes in depending of used methods. Among women which had osteoporosis of femoral neck by DXA, 73% had osteoporosis, 24% - osteopenia, 3% - norma data by DXR. Sensitivity of DXR indexes ranging was from moderate to high, but specificity was low (with femoral neck - 73% and 38%, total hip - 78% and 22%, lumbar spine - 56% and 18%, total body - 68% and 24% accordingly). Such sensitivity and specificity increased when combining DXR with the ten years probability of hip fracture without BMD (FRAX) (with femoral neck - 86% and 63%, total hip - 89% and 54%, lumbar spine - 84% and 50%, total body - 89% and 53% accordingly). Sensitivity was higher in patients with fractures in comparison with women without fractures, (with femoral neck - 82% and 64%, total hip - 80% and 75%, lumbar spine - 82% and 56%, total body - 82% and 50% accordingly), but specificity was low in both groups. …

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