Academic journal article International Journal of Child Health and Human Development

Anatomical and Topological Connectivity Reveal Different Attributes of Disrupted Small-World Networks in Autistic Children

Academic journal article International Journal of Child Health and Human Development

Anatomical and Topological Connectivity Reveal Different Attributes of Disrupted Small-World Networks in Autistic Children

Article excerpt

Anatomical MRI and diffusion tensor imaging (DTI) studies have shown that complex architecture of the brain networks follow a small-world behavior. Recent findings in autism spectrum disorder (ASD) point out that disrupted functional connectivity is a key feature of its pathophysiology. The influence of underlying white matter microstructure (anatomical connectivity) and concurrent morphometric changes between brain structures (morphological connectivity) have not been elucidated. Graph theory has become a powerful and versatile approach for the mathematical treatment of those complex interaction patterns. However, the high degree of variability from the adult brain data makes standard processing methodologies suboptimal for pediatric neuroimaging studies.

Here, we aimed to investigate whether the two brain hemispheres demonstrate dissimilar small world attributes in anatomical and morphological connectivity. Statistical similarities between connectivity descriptors were also explored. We used an unbiased, age-appropriate MRI pediatric template for spatial normalization. SPM, IBASPM, DSI-Studio and homemade software tools were used for image processing and analysis. Binarized connectivity graphs were built to study small-world attributes. Surface area and anatomical connection probabilities are employed as anatomical and morphometric descriptors, respectively.

This methodology enabled us to study the complex network properties of the children's brain. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.