Academic journal article NACTA Journal

Thinking of Epistasis as Playing in a Restricted Playground

Academic journal article NACTA Journal

Thinking of Epistasis as Playing in a Restricted Playground

Article excerpt

Inheritance through a single gene (H), when epistasis does not interfere, is straightforward. In this case, genotypic frequencies at H locus i.e., 1HH:2Hh:1hh would lead to phenotypic ratio of 3H:1h, when H is dominant over h. Under the two types of dominant and recessive epistasis, the functionality of the hypostatic locus (H) is interfered by allelic state of the epistatic locus (E). Let's imagine that E alone has the 3:1 ratio. Under both dominant and recessive epistasis, the locus E sets specific rules for expression of the trait of interest. These rules define the borders of a restricted playground for the H gene to be in effect. One possible rule set by E is that H can only be in effect if and only if E locus is homozygous recessive (ee). This simply means that H has access to only % of the playground (Fig 1a). Within this % area, the locus H will impose its 3H:1h effect. The other % is already set by the dominant phenotype of E locus (whatever that could be). …

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