Alcohol Research

Journal covering alcohol research.

Articles from Vol. 31, No. 1, 2008

A Systems-Based Computational Model of Alcohol's Toxic Effects on Brain Development
Important stages during neurodevelopment include the generation of new nerve cells (i.e., neurogenesis), differentiation and migration of these cells to their final location in the brain, formation of connections with neighboring cells (i.e., synaptogenesis),...
Commentary: Systems Biology and Its Relevance to Alcohol Research
Systems biology, a new scientific discipline, aims to study the behavior of a biological organization or process in order to understand the function of a dynamic system. This commentary will put into perspective topics discussed in this issue of Alcohol...
Mathematical Modeling of Complex Biological Systems: From Parts Lists to Understanding Systems Behavior
To understand complex biological systems such as cells, tissues, or even the human body, it is not sufficient to identify and characterize the individual molecules in the system. It also is necessary to obtain a thorough understanding of the interaction...
Metabolomics in Alcohol Research and Drug Development
Developers of new medications need to describe and predict the functional attributes of test compounds administered to cells, animals, and humans. Today, researchers increasingly appreciate the role that intermediary products (i.e., metabolites) generated...
Proteomic Approaches for Studying Alcoholism and Alcohol-Induced Organ Damage
Proteomics research is concerned with the analysis of all proteins found in an organism, tissue, cell type, or cellular structure. The shotgun proteomic approach, which involves two-dimensional gel electrophoresis or liquid chromatography combined with...
Systems Biology in the Study of Neurological Disorders: Focus on Alzheimer's Disease
Systems biology approaches may be useful for studying the mechanisms underlying alcohol's harmful effects on the brain. Such approaches already are used in the study of Alzheimer's disease (AD), a progressive neurodegenerative disorder that, with the...
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