Alcohol Research

Journal covering alcohol research.

Articles from Vol. 24, No. 3, 2000

Animal Models of Psychiatric Disorders and Their Relevance to Alcoholism
Animal models are important tools in the study of psychiatric disorders, including alcoholism,' because they allow the use of research methods that cannot be used for ethical reasons in humans. Consequently, scientists have developed numerous approaches...
Applications of Transgenic and Knockout Mice in Alcohol Research
Multiple genetic and environmental factors contribute to the development of alcoholism. Researchers attempting to elucidate the roles of specific genes in alcoholism risk have benefited from advances in genetic engineering. Two important tools used by...
Future Directions in Alcoholism Research: Genomics and Gene Transfer
Alcohol affects the process by which genes direct the synthesis of proteins (ie., expression). Therefore, patterns of gene expression in the presence of alcohol can help scientists identify the specific molecular sites of alcohol's actions within the...
Genetics of Alcohol-Induced Behaviors in Drosophila
Researchers frequently study the fruit fly Drosophila melanogaster as a model system for mammalian development and behavior. Drosophila appear resistant to alcohol's toxic effects and display many behaviors resembling intoxication (e.g., impaired motor...
Quantitative Trait Locus Analysis
Alcoholism is a quantitative disorder that is caused by the combined influences of numerous genes (ie., quantitative trait loci [QTLs]) and environmental factors. To identify QTLs for alcoholism, researchers compare subject groups (eg., inbred mouse...
Selected Lines and Inbred Strains: Tools in the Hunt for the Genes Involved in Alcoholism
In their quest to elucidate the genetic influences contributing to alcoholism, researchers have long used selected lines and inbred strains of rodents. Selected lines are obtained by repeatedly mating those animals within a population that show extremely...
The Candidate Gene Approach
Alcoholism has a significant genetic basis, and identifying genes that confer a susceptibility to alcoholism will aid clinicians in preventing and effectively treating the disease. One commonly used technique to identify genetic risk factors for complex...
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