Alcohol Research

Journal covering alcohol research.

Articles from Vol. 31, No. 3, Fall

Communication Networks in the Brain: Neurons, Receptors, Neurotransmitters, and Alcohol
The behavioral effects of alcohol are produced through its actions on the central nervous system (CNS) and, in particular, the brain. Synaptic transmission-the process by which neurons in the CNS communicate with one another-is a particular target...
Conclusions
Although alcohol affects almost all tissues and organs in the body, the brain can be considered the most significant target of alcohol use and/or abuse. Thus alcohol's effects on the brain are immediate and widespread, ranging from effects on normal...
Expression Quantitative Trait Loci and the PhenoGen Database
KEY WORDS: Genetic theory of alcohol and other drug use; microarray technologies; microarray analysis; phenotype; candidate gene; qualitative trait locus (QTL), expression qualitative trait locus (eQTL), gene expression; gene transcription; genetics;...
From Event-Related Potential to Oscillations: Genetic Diathesis in Brain (Dys)function and Alcohol Dependence
KEYWORDS: Alcoholism; alcohol disorders; children of alcoholics; alcohol-related genetic factors; risk factors; genetic markers; brain function; brain wave; brain activity diagnosis; neuroimaging; electroencephalography (EEG); event-related potential...
Integrative Genetic Analysis of Alcohol Dependence Using the GeneNetwork Web Resources
KEY WORDS: Alcoholism; genetic theory of alcohol and other drug use; alcohol-related phenotypes; genetic factors; environmental factors; genetic traits; DNA variants; candidate genes; genetic strains; animal models; laboratory rats; laboratory mice;...
Interval-Specific Congenic Animals for High-Resolution Quantitative Trait Loci Mapping
KEY WORDS: Genetic theory of alcohol and other drug use; genetics and heredity; behavioral phenotypes, genetic trait, quantitative traits; quantitative trait locus (QTL), QTL mapping; congenics; interval-specific congenics (ISCs); congenic strains;...
Laser-Assisted Microdissection
KEY WORDS: Alcohol-related research; alcohol and other drug effects and consequences; brain; brain cells; brain function; brain structure; laser-assisted microdissection (LMD); laser capture; laser microbeam; reverse-transcription polymerase chain...
Magnetic Resonance Imaging Approaches for Studying Alcoholism Using Mouse Models
KEY WORDS: Alcoholism; alcohol and other drug effects and consequences; animal studies; laboratory mice; mouse brain; brain function; brain structure; neuroimaging; magnetic resonance imaging (MR/); functional magnetic resonance imaging (fMRI), pharmacological...
Neurobiology of Alcohol Dependence: Focus on Motivational Mechanisms
Alcoholism, also called dependence on alcohol, is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. The development of alcoholism is characterized by frequent episodes of intoxication, preoccupation with...
On the Use of Short-Interfering RNA to Study Alcohol-Related Genes
KEY WORDS: Alcohol consumption; AOD effects and consequences; brain; brain function; genetic factors; DNA; RNA; short-interfering RNAs (siRNAs), silencing One strategy to determine the contribution of individual genes to the development of complex...
Positron Emission Tomography as a Tool for Studying Alcohol Abuse
KEY WORDS: Alcohol-related research; alcohol and other drug (AOD) effects and consequences; brain; brain function; brain imaging; positron emission tomography (PET); radiotracers; radioisotopes; ([sup.18]F)-fluoro-2-deoxyglucose (FDG); neurotransmitters;...
Proteomic Solutions for Analytical Challenges Associated with Alcohol Research
KEY WORDS: Alcohol dependence; genetic theory of alcohol and other drug use; genetic trait; brain; animal models; proteins, protein analysis; proteomics; mass spectrometry; peptides. Alcohol addiction is a complex disease with both hereditary and...
Quantitative Trait Locus Analysis: Multiple Cross and Heterogeneous Stock Mapping
KEY WORDS: Genetic theory of alcohol and other drug use; genetic factors; environmental factors; behavioral phenotype; behavioral trait; quantitative trait gene (QTG); inbred animal strains; recombinant inbred (RI) mouse strains; quantitative traits;...
Single-Nucleotide Polymorphism Masking
KEY WORDS: expression; genome; genetic analysis; microarray analysis; singular nucleotide polymorphism (SNP); SNP masking; mouse genome; laboratory mice; animal models As described in other articles in this Special Section, microarrays are widely...
Strategies to Study the Neuroscience of Alcoholism: Introduction
Alcohol use and abuse are widespread in the U.S. population. Moreover, for each drinker, alcohol consumption, particularly at excessive levels, has a vast range of effects on the body. Accordingly, research programs aimed at understanding alcohol's...
The Use of Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging in Alcohol Research
KEY WORDS: Alcoholism; alcohol dependence; alcohol and other drugs effects and consequences; brain function; brain structure; neuropathology; neuroimaging; magnetic resonance imaging (MR/); functional magnetic resonance imaging (fMRI), animal studies;...
Translational Studies of Alcoholism: Bridging the Gap
What currently is known about alcohol's effects on the brain has benefited from translational research-the parallel study of humans with alcohol dependence and of animal models that mimic targeted aspects of this complex disease. Human studies provide...
Viral Delivery of Small-Hairpin RNAS for Reducing Gene Expression in the Rodent Brain
KEY WORDS: Alcohol and other drug disorder (AODD); genetic theory of AOD use (AODU), brain; genetics and heredity; gene knockout technology; RNA interference (RNAi), small hairpin RNAS (shRNAs), viral delivery systems; lentivirus; oligonucleotides...
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