Alcohol Research

Journal covering alcohol research.

Articles from Vol. 34, No. 3, 2012

Alcohol Dependence and Genes Encoding [Alpha]2 and [Gamma]1 GABA^sub A^ Receptor Subunits: Insights from Humans and Mice
One approach to identifying the causes of alcoholism, particularly without crossing ethical boundaries in human subjects, is to look at the person's genome (and particularly at the variations that naturally arise in the DNA) to identify those variations...
Assessing the Genetic Risk for Alcohol Use Disorders
The past two decades have witnessed a revolution in the field of genetics which has led to a rapid evolution in the tools and techniques available for mapping genes that contribute to genetically complex disorders such as alcohol dependence. Research...
A Watershed Year for an Update on the Genetics of Alcoholism
It is easy to think of genetics as the study of genes, but given our current knowledge of genetics, this definition is now considered inadequate. Genetics is the study of differences among individuals- even between identical twins. We know that some...
Bridging Animal and Human Models: Translating from (and to) Animal Genetics
Genetics play an important role in the development and course of alcohol abuse, and understanding genetic contributions to this disorder may lead to improved preventative and therapeutic strategies in the future. Studies both in humans and in animal...
Circadian Genes, the Stress Axis, and Alcoholism
The body's internal system to control the dally rhythm of the body's functions (i.e., the circadian system), the body's stress response, and the body's neurobiology are highly interconnected. Thus, the rhythm of the circadian system impacts alcohol use...
Discovering Genes Involved in Alcohol Dependence and Other Alcohol Responses: Role of Animal Models
The genetic determinants of alcoholism still are largely unknown, hindering effective treatment and prevention. Systematic approaches to gene discovery are critical if novel genes and mechanisms involved in alcohol dependence are to be identified. Although...
Epigenetics-Beyond the Genome in Alcoholism
Genetic and environmental factors play a role in the development of alcoholism. Whole-genome expression profiling has highlighted the importance of several genes that may contribute to alcohol abuse disorders. In addition, more recent findings have added...
Genes Contributing to the Development of Alcoholism: An Overview
Genetic factors (i.e., variations in specific genes) account for a substantial portion of the risk for alcoholism. However, identifying those genes and the specific variations involved is challenging. Researchers have used both case-control and family...
Genes Encoding Enzymes Involved in Ethanol Metabolism
The effects of beverage alcohol (ethanol) on the body are determined largely by the rate at which it and its main breakdown product, acetaldehyde, are metabolized after consumption. The main metabolic pathway for ethanol involves the enzymes alcohol...
Genetic and Genomic Web Resources for Research on Alcohol Use and Abuse
There are two major ways of publishing scientific data and results: (1) the standard peer- reviewed paper, which dates back to volume 1 of the Philosophical Transactions of the Royal Society in 1665; and (2) online distribution of data, resources, and...
Genetics Glossary
Agonist: An agent that mimics the actions or effects of another agent at a receptor (e.g., a drug that mimics the effects of a neurotransmitter).Allele: One of two or more forms of a gene that reside at the same position on a pair of chromosomes; different...
Genetics Primer
Genetics is the study of genes- the heritable information that contains the codes for proteins and other molecules which form and maintain an organisms structure and function. In most organisms, these genes are found in strands of deoxyribonucleic acid...
Identifying Gene Networks Underlying the Neurobiology of Ethanol and Alcoholism
For complex disorders such as alcoholism, identifying the genes linked to these diseases and their specific roles is difficult. Traditional genetic approaches, such as genetic association studies (including genome-wide association studies) and analyses...
Identifying Genetic Variation for Alcohol Dependence
Researchers are using various strategies to identify the genes that may be associated with alcoholism. The initial efforts primarily relied on candidate gene and linkage studies; more recently, however, modern advances in genotyping have resulted in...
Immune Function Genes, Genetics, and the Neurobiology of Addiction
The neuroimmune system (i.e., the immune system and those components of the nervous system that help regulate immune responses), and in particular the innate immune system, play a role in the development of addictions, including alcoholism, particularly...
New Look and New Title for NIAAA's Flagship Publication
In 2010, NIAAA marked a significant milestone, celebrating 40 years of research on alcohol abuse and alcoholism. Throughout this time, NLAAAs journal has played an important role, raising awareness about topics in alcohol research and ensuring that important...
The Impact of Gene-Environment Interaction on Alcohol Use Disorders
This article describes three types of gene-environment interactions and the challenges inherent in interpreting these interactions. It also reports on what is known about gene-environment interactions in the field of alcohol use disorders (AUDs). Twin...
Using Genetically Engineered Animal Models in the Postgenomic Era to Understand Gene Function in Alcoholism
Over the last 50 years, researchers have made substantial progress In Identifying genetic variations that underlie the complex phenotype of alcoholism. Not much Is known, however, about how this genetic variation translates Into altered biological function....
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