Genetics

Professional journal providing news and analysis on field of genetics. Features special reports such as policy reviews and awards.

Articles from Vol. 187, No. 4, April

Analysis of Stunter1, a Maize Mutant with Reduced Gametophyte Size and Maternal Effects on Seed Development
ABSTRACTMany higher eukaryotes have evolved strategies for the maternal control of growth and development of their offspring. In higher plants this is achieved in part by postmeiotic gene activity controlling the development of the haploid female gametophyte....
A Screenable in Vivo Assay to Study Proteostasis Networks in Caenorhabditis Elegans
ABSTRACTIn eukaryotic cells, the ubiquitin/proteasome system (UPS) is a key determinant of proteostasis as it regulates the turnover of damaged proteins. However, it is still unclear how the UPS integrates intrinsic and environmental challenges to promote...
Augmented Annotation of the Schizosaccharomyces Pombe Genome Reveals Additional Genes Required for Growth and Viability
ABSTRACTGenome annotation is a synthesis of computational prediction and experimental evidence. Small genes are notoriously difficult to detect because the patterns used to identify them are often indistinguishable from chance occurrences, leading to...
Cohesin Plays a Dual Role in Gene Regulation and Sister-Chromatid Cohesion during Meiosis in Saccharomyces Cerevisiae
ABSTRACTSister-chromatid cohesion mediated by cohesin ensures proper chromosome segregation during cell division. Cohesin is also required for postreplicative DNA double-strand break repair and gene expression. The molecular mechanisms of these diverse...
Functional Relevance of CpG Island Length for Regulation of Gene Expression
ABSTRACTCpG islands mark CpG-enriched regions in otherwise CpG-depleted vertebrate genomes. While the regulatory importance of CpG islands is widely accepted, it is little appreciated that CpG islands vary greatly in lengths. For example, CpG islands...
Gene Expression Differences among Primates Are Associated with Changes in a Histone Epigenetic Modification
ABSTRACTChanges in gene regulation are thought to play an important role in speciation and adaptation, especially in primates. However, we still know relatively little about the mechanisms underlying regulatory evolution. In particular, the extent to...
Genetic Analysis Implicates the Set3/Hos2 Histone Deacetylase in the Deposition and Remodeling of Nucleosomes Containing H2A.Z
ABSTRACTHistone variants and histone modification complexes act to regulate the functions of chromatin. In Saccharomyces cerevisiae the histone variant H2A.Z is encoded by HTZ1. Htz1 is dispensable for viability in budding yeast, but htz1? is synthetic...
Inference of Mutation Parameters and Selective Constraint in Mammalian Coding Sequences by Approximate Bayesian Computation
ABSTRACTWe develop an inference method that uses approximate Bayesian computation (ABC) to simultaneously estimate mutational parameters and selective constraint on the basis of nucleotide divergence for protein-coding genes between pairs of species....
Maximally Efficient Modeling of DNA Sequence Motifs at All Levels of Complexity
ABSTRACTIdentification of transcription factor binding sites is necessary for deciphering gene regulatory networks. Several new methods provide extensive data about the specificity of transcription factors but most methods for analyzing these data to...
Modifier Genes for Mouse Phosphatidylinositol Transfer Protein [Alpha] (Vibrator) That Bypass Juvenile Lethality
ABSTRACTPhosphatidylinositol transfer proteins (PITPs) mediate lipid signaling and membrane trafficking in eukaryotic cells. Loss-of-function mutations of the gene encoding PITPa in mice result in a range of dosage-sensitive phenotypes, including neurological...
Ploidy Dictates Repair Pathway Choice under DNA Replication Stress
ABSTRACTThis study reports an unusual ploidy-specific response to replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in yeast. The corresponding mouse allele, Mcm4^sup Chaos3^, predisposes mice to mammary gland...
Previous Recipients of GSA Awards
Thomas Hunt Morgan Medal1981 Barbara McClintock and Marcus M. Rhoades1982 Sewall Wright1983 Edward B. Lewis1984 George W. Beadle and R. Alexander Brink1985 Herschel L. Roman1986 Seymour Benzer1987 James F. Crow1988 Norman H. Giles1989 Dan L. Lindsley1990...
Proximodistal Patterning in the Drosophila Leg: Models and Mutations
ABSTRACTLimbs have a proximodistal axis that usually is not apparent early in development, a striking example of epigenesis. The proximodistal axis was the subject of experimental and theoretical study before any molecular genetic understanding emerged....
Role of Elongator Subunit Elp3 in Drosophila Melanogaster Larval Development and Immunity
ABSTRACTThe Elongator complex has been implicated in several cellular processes, including gene expression and tRNA modification. We investigated the biological importance of the Elp3 gene in Drosophila melanogaster. Deletion of Elp3 results in larval...
Targeted Introgression of a Wheat Stem Rust Resistance Gene by DNA Marker-Assisted Chromosome Engineering
ABSTRACTChromosome engineering is a useful strategy for transfer of alien genes from wild relatives into modern crops. However, this strategy has not been extensively used for alien gene introgression in most crops due to low efficiency of conventional...
The 19 Genomes of Drosophila: A BAC Library Resource for Genus-Wide and Genome-Scale Comparative Evolutionary Research
ABSTRACTThe genus Drosophila has been the subject of intense comparative phylogenomics characterization to provide insights into genome evolution under diverse biological and ecological contexts and to functionally annotate the Drosophila melanogaster...
The 2011 Genetics Society of America Elizabeth W. Jones Award for Excellence in Education: Peter Bruns
IT is a common sight at many life science education meetings across the nation to find Peter Bruns listening in with rapt attention to a discussion of a new pedagogical tool or, more likely, the personal triumph of a set of students whom he has never...
The 2011 Genetics Society of America Medal: John Carlson
IN his 1985 book "Late Night Thoughts on Listening to Mahler's Ninth Symphony," Lewis Thomas reflected on the sense of smell and wrote: "I should think we might fairly gauge the future of biological science, centuries ahead, by estimating the time it...
The 2011 George W. Beadle Award: Joseph R. Ecker
THE 2011 George W. Beadle Medal for outstanding contributions to the genetics community is awarded to Joseph R. Ecker. Joe is one of those rare scientists who has made fundamental discoveries in his own laboratory while also generating the genomic resources...
The 2011 Novitski Prize: Abby F. Dernburg
EACH year the Genetics Society of America celebrates the achievements of the extraordinarily creative Drosophila geneticist Edward Novitski (1918- 2006) by awarding the Edward Novitski Prize. This award, which is generously supported by the Novitski...
The 2011 Thomas Hunt Morgan Medal: James Haber
IN recognition of his lifetime contributions to the field of genetics, James Haber is the 2011 recipient of the Thomas Hunt Morgan medal awarded by the Genetics Society of America (GSA). Using budding yeast as a model system throughout his career, Jim...
The Effects of Weak Genetic Perturbations on the Transcriptome of the Wing Imaginal Disc and Its Association with Wing Shape in Drosophila Melanogaster
ABSTRACTA major objective of genomics is to elucidate the mapping between genotypic and phenotypic space as a step toward understanding how small changes in gene function can lead to elaborate phenotypic changes. One approach that has been utilized is...
Transcriptional Networks for Alcohol Sensitivity in Drosophila Melanogaster
ABSTRACTUnderstanding the genetic architecture of polygenic traits requires investigating how complex networks of interacting molecules mediate the effect of genetic variation on organismal phenotypes. We used a combination of P-element mutagenesis and...