Magazine article Clinical Psychiatry News

High-Dose Quetiapine Appears Safe, Effective in Older Patients. (Retrospective Chart Review)

Magazine article Clinical Psychiatry News

High-Dose Quetiapine Appears Safe, Effective in Older Patients. (Retrospective Chart Review)

Article excerpt

HONOLULU -- Elderly patients with dementia seem to do well on quetiapine in dosages greater than the 200 mg/day maximum recommended by the Centers for Medicare and Medicaid Services, Dr. Franco Sicuro said in a poster presentation at the annual meeting of the American Association for Geriatric Psychiatry.

These findings are based on a chart review of 28 patients with a mean age of 78.5 years who were treated at a single psychiatric inpatient unit, Dr. Sicuro said at the meeting.

In this study--the first to evaluate the safety and efficacy of high-dose quetiapine (Seroquel) in this population--the patients experienced a marked improvement in clinical global impression ratings and few adverse effects, he said.

On admission, 16 patients already were taking quetiapine at a mean dosage of 330 mg/day The mean dosage increase for all patients during their hospitalization was 262 mg/day, and the mean dosage at discharge was 450 mg/day.

The mean length of stay was 19 days. Agitation and aggression were the most common reasons for admission, but inappropriate sexual behavior and delusions, hallucinations, and paranoia also were common.

Of the 28 patients in the study 14 had comorbid depression and required higher mean daily dosages of quetiapine than did the patients who weren't depressed: 539 mg vs. …

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