Magazine article Clinical Psychiatry News

Renal Insufficiency Raises Risk for Dementia

Magazine article Clinical Psychiatry News

Renal Insufficiency Raises Risk for Dementia

Article excerpt

SAN DIEGO -- Older adults with moderate renal insufficiency as indicated by an elevated serum creatinine level are at 58% higher risk for vascular-type dementia, Dr. Stephen L. Seliger reported in a poster session at the annual meeting of the American Society of Nephrology.

"Those patients need more attention and more screening for the earlier stages of disease," said Dr. Seliger of the department of medicine at the University of Washington, Seattle.

Correcting renal insufficiency can do more than benefit the kidneys. "Efforts to prevent or slow the rate of renal disease might also have the benefit of reducing the risk of dementia," he added.

In what he said is the first study of its kind, Dr. Seliger and his associates analyzed data from the Cardiovascular Health Cognition Study, an ancillary component of the National Institutes of Health-funded Cardiovascular Health Study designed to identify rates and correlates of dementia among the elderly.

The 3,449 community-dwelling men and women received cranial MRI imaging, serum creatinine testing, and a complete medical exam at baseline and were followed for a median of 6 years.

Prevalent and incident dementia was diagnosed using neuropsychological testing, patient and caregiver interviews, and neurologic testing.

Cox proportional hazard models were used to determine the association between renal function and incident dementia, with adjustment for possible confounding variables. …

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