Magazine article Clinical Psychiatry News

Testosterone Replacement Curbs Inflammatory Cytokines

Magazine article Clinical Psychiatry News

Testosterone Replacement Curbs Inflammatory Cytokines

Article excerpt

NEW ORLEANS -- Testosterone replacement therapy may be of cardiovascular benefit in a sizable proportion of men with coronary heart disease, Dr. Chris J. Malkin said at the annual meeting of the American College of Cardiology.

Testosterone replacement reduced elevated levels of inflammatory cytokines in a group of men with CHD and symptomatic androgen deficiency in a randomized, placebo-controlled trial. This dialing-down of the systemic inflammatory state may have salutary stabilizing effects on atherosclerotic plaques, explained Dr. Malkin of Royal Hallamshire Hospital, Sheffield, England.

These observations, if confirmed in larger studies incorporating clinical event end points, could have broad implications. The prevalence of hypogonadism is known to be elevated in men with CHD; in one representative study, the rate was 23%.

Dr. Malkin reported on 20 men with CHD and androgen deficiency symptoms who were randomized to 1 month of testosterone replacement or placebo, then crossed over to the other arm for a second month. Baseline mean total testosterone in study participants was 6.7 nmol/L; the lower limit of normal is 8.3 nmol/L.

Of the inflammatory cytokines measured in the study, the greatest impact of testosterone replacement was on tumor necrosis factor (TNF)-[alpha]. …

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