Magazine article Clinical Psychiatry News

Alzheimer's Risk Factor May Affect Cortical Atrophy

Magazine article Clinical Psychiatry News

Alzheimer's Risk Factor May Affect Cortical Atrophy

Article excerpt

BALTIMORE -- Nondemented adults with the apolipoprotein E [epsilon]4 genetic risk for Alzheimer's disease may have a higher risk for accelerated brain atrophy, Prabha Siddarth, Ph.D., said in a poster presentation at the American Association for Geriatric Psychiatry's annual meeting.

The 23 participants in the longitudinal study were aged 50-82 years. Twelve adults with apolipoprotein E [epsilon]4 (apo E4), with a mean age of 63.3 years and 15.3 mean years of education were compared with 11 adults without apo E4, whose mean age was 66.8 years and who had 16.5 years of education. There were nine women (75%) in the apo E4 group and eight women (73%) in the group without apo E4.

Both groups had similar scores on Mini-Mental State Examination: 28.5 for the apo E4 group and 29.3 for the non-apo E4 group. Ten members of the apo E4 group had a family history of Alzheimer's, compared with 8 in the non-apo E4 group.

MRI brain scans were done at baseline and during a 2-year follow-up to evaluate changes in brain shape and tissue distribution, said Dr. …

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