Magazine article Clinical Psychiatry News

Hippocampus Size on MRI Flags Risk of AD

Magazine article Clinical Psychiatry News

Hippocampus Size on MRI Flags Risk of AD

Article excerpt

PHILADELPHIA. -- An MRI brain image that shows a small hippocampus can identify those patients with mild cognitive impairment who have the highest risk of progressing to Alzheimer's disease, based on a study with 190 patients.

Patients who had a small hippocampus, measured with MRI, at the time they were first diagnosed with mild cognitive impairment (MCI), had a 2.17-fold increased risk of developing Alzheimer's disease (AD) during the next 3 years, compared with patients with a relatively larger hippocampus, Dr. Charles DeCarli reported at the Ninth International Conference on Alzheimer's Disease and Related Disorders.

This analysis was a substudy of a 769-patient study that assessed the efficacy of donepezil or vitamin E to slow the progression of MCI. The results from the larger study were also reported at the conference, presented by the Alzheimer's Association. (See related story on page 1.)

In the substudy, the brains of 190 patients were imaged using high-resolution, T1-weighted MRI at the time they entered the study. …

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